Compound ID | 1289

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Ethyl bromopyruvate

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting; Antibiofilm;
Spectrum of activity: Gram-positive, Gram-negative & Antimycobacterial
Mechanism of action: Targets the glycolytic and glyoxylate pathway
Target Pathogen: Broad spectrum activity including Mycobacterium tuberculosis
Description: Derivative of 3-bromo-pyruvic acid (3- BPA)
Institute where first reported: Department of Biotechnology, National Institute of Pharmaceutical Education and Research; Division of Microbiology, Council of Scientific and Industrial Research-Central Drug Research Institute (CSIR-CDRI); Council of Scientific and Industrial Research-Institute of Microbial Technology (CSIR-IMTECH)
Year first mentioned: 2009
Development status: Experimental
Chemical structure(s):
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Molecular weight: 195.01
Iso. SMILES: CCOC(=O)C(=O)CBr
InChI Key: VICYTAYPKBLQFB-UHFFFAOYSA-N
Can. SMILES: CCOC(=O)C(=O)CBr
InChI: InChI=1S/C5H7BrO3/c1-2-9-5(8)4(7)3-6/h2-3H2,1H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/66144
Guide to Pharmacology: ethyl bromopyruvate
Citation: https://doi.org/10.1093/jac/dky555

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