Compound ID | 1294
NAB815
Class: Polymyxin
| Spectrum of activity: | Gram-negative |
| Details of activity: | Disrupts the outer membrane by direct interaction with the lipid A component of the LPS and and disrupts the physical integrity of the phospholipid bilayer of the inner membrane, and possibly additional modes of action. |
| Institute where first reported: | Northern Antibiotics Ltd, Technopolis; Division of Clinical Microbiology, Helsinki University Hospital; Department of Bacteriology and Immunology, Helsinki University Medical School; Statens Serum Institut, Copenhagen, Denmark. |
| Year first mentioned: | 2017 |
| Highest developmental phase: | Preclinical |
| Development status: | Active |
| External links: | |
| Citation: | https://academic.oup.com/jac/article/73/2/452/4629255?searchresult=1 |
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