Compound ID | 1301
M33
Class: Antimicrobial peptide
| Agent Type: | Synthetic; Direct acting; |
| Spectrum of activity: | Gram-negative |
| Mechanism of action: | Membrane-active agent |
| Target Pathogen: | Bactericidal activity against colistin- susceptible and -resistant isolates of Pseudomonas aeruginosa, and against colistin-susceptible Klebsiella pneumoniae. Combined therapy on XDR Acinetobacter baumannii, Klebsiella pneumoniae and Pseudomonas aeruginosa strains, gave synergy for M33/meropenem on two of the six strain, for M33/rifampin on three out of six strains, for M33/aztreonam on three out of six strains and for M33/tobramycin on one out of six strains |
| Institute where first reported: | University of Siena; University of Florence; Erasmus Mc; Medical Microbiology & Infectious Diseases; Erasmus University Medical Centre (Erasmus Mc); Medical Microbiology & Infectious Diseases; University of Florence; Forence Careggi University Hospital; Don Carlo Gnocchi Foundation; Clinical Microbiology and Virology Unit, Florence Careggi University Hospital, Florence; University of Siena; Medical Biotechnology; University of Siena; Department of Medical Biotechnology |
| Year first mentioned: | 2017 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://doi.org/10.1007/s00726-011-1103-z |
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