Compound ID | 1305

Update compound information

LN-1-255

Class: Beta-lactamase inhibitor (inhibitor of class D carbapenemases of A. baumannii)

Spectrum of activity: Gram-negative
Details of activity: Effective against class D carbapenemases of A. baumannii
Institute where first reported: I.N.I.B.I.C; Microbiology
Year first mentioned: 2017
Highest developmental phase: Preclinical
Development status: Active
Chemical structure(s):
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Molecular weight: 510.45
Iso. SMILES: C[C@@]1([C@@H](N2[C@H](S1(=O)=O)/C(=C\C3=CC=CC=N3)/C2=O)C(=O)[O-])COC(=O)CC4=CC(=C(C=C4)O)O.[Na+]
InChI Key: OISRDGHGSAOFKW-OIGABSMWSA-M
Can. SMILES: C[C@]1(COC(=O)CC2=CC=C(C(=C2)O)O)[C@H](C(=O)[O-])N3C(=O)/C(=C/C4=NC=CC=C4)/[C@H]3S1(=O)=O.[Na+]
InChI: InChI=1S/C22H20N2O9S.Na/c1-22(11-33-17(27)9-12-5-6-15(25)16(26)8-12)18(21(29)30)24-19(28)14(20(24)34(22,31)32)10-13-4-2-3-7-23-13;/h2-8,10,18,20,25-26H,9,11H2,1H3,(H,29,30);/q;+1/p-1/b14-10-;/t18-,20+,22-;/m0./s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/23672118
Citations:
  • https://aac.asm.org/content/63/10/e01092-19
  • https://www.escmid.org/escmid_publications/escmid_elibrary/?q=The+combination+of+carbapenems+and+the+B-lactamase+inhibitor+LN-1-255+is+effective+against+class+D+carbapenemases+of+Acinetobacter+baumannii&id=2173&L=0&x=0&y=0

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