Compound ID | 1314

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Chinfloxacin

Class: Fluoroquinolone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: DNA synthesis inhibitor
Target Pathogen: Active against biothreat pathogens
Institute where first reported: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, and bClinical Laboratory, Zhangshu People’s Hospital, Zhangshu, PR China
Year first mentioned: 2012
Highest development stage: Phase 1 (in China, ChiCTR-TRC-10001619, ChiCTR1800015906)
Development status: Active
Chemical structure(s):
Click here for structure editor
Molecular weight: 437.41
Iso. SMILES: C1CC2CN(CC2NC1)C3=C(C=C4C(=C3OC(F)F)N(C=C(C4=O)C(=O)O)C5CC5)F
InChI Key: KNLARSZRTBDTIA-UHFFFAOYSA-N
Can. SMILES: C1CC2CN(CC2NC1)C3=C(C4=C(C=C3F)C(=O)C(=CN4C5CC5)C(=O)O)OC(F)F
InChI: InChI=1S/C21H22F3N3O4/c22-14-6-12-16(27(11-3-4-11)8-13(18(12)28)20(29)30)19(31-21(23)24)17(14)26-7-10-2-1-5-25-15(10)9-26/h6,8,10-11,15,21,25H,1-5,7,9H2,(H,29,30)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/75253538
Guide to Pharmacology: chinfloxacin
Citations:
  • https://doi.org/10.1093/jac/dkr557
  • https://aac.asm.org/content/62/12/e01087-18

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