Compound ID | 1315

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Antofloxacin

Class: Fluoroquinolone

Spectrum of activity: Gram-negative
Details of activity: Antofloxacin hydrochloride demonstrates clinical and bacteriological efficacies similar to levofloxacin for the treatment of AECB and AP.
Institute where first reported: Institute of Clinical Pharmacology, First Hospital, Peking University, Beijing 100083, China.
Year first mentioned: 2008
Highest development stage: Phase 2
Development status: Active
Chemical structure(s):
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Molecular weight: 376.38
Iso. SMILES: C[C@H]1COC2=C3N1C=C(C(=O)C3=C(C(=C2N4CCN(CC4)C)F)N)C(=O)O
InChI Key: MHFCVNDHFSOKMK-VIFPVBQESA-N
Can. SMILES: C[C@H]1COC2=C(C(=C(C3=C2N1C=C(C3=O)C(=O)O)N)F)N4CCN(C)CC4
InChI: InChI=1S/C18H21FN4O4/c1-9-8-27-17-14-11(16(24)10(18(25)26)7-23(9)14)13(20)12(19)15(17)22-5-3-21(2)4-6-22/h7,9H,3-6,8,20H2,1-2H3,(H,25,26)/t9-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/24806573
Guide to Pharmacology: antofloxacin
Citations:
  • https://www.ncbi.nlm.nih.gov/pubmed/18240275?dopt=Abstract
  • https://www.ncbi.nlm.nih.gov/pubmed/20938175?dopt=Abstract
  • https://aac.asm.org/content/62/1/e01281-17

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