Compound ID | 1316

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PFK-158

Class: Glycolytic inhibitor

Spectrum of activity: Gram-negative
Details of activity: PFK-158 decrease the MICs of colistin to eradicates both colistin-susceptible and colistin-resistant (mcr-1 or HLCR) Enterobacteriaceae in vitro. It also enhances the efficacy of colistin in vivo.
Combined with other compounds: Yes
Institute where first reported: Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
Highest developmental phase: Phase 1
Development status: Active
Chemical structure(s):
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Molecular weight: 328.29
Iso. SMILES: C1=CC(=CC2=C1C=CC(=N2)/C=C/C(=O)C3=CC=NC=C3)C(F)(F)F
InChI Key: IAJOMYABKVAZCN-AATRIKPKSA-N
Can. SMILES: C1=C2C=CC(=NC2=CC(=C1)C(F)(F)F)/C=C/C(=O)C3=CC=NC=C3
InChI: InChI=1S/C18H11F3N2O/c19-18(20,21)14-3-1-12-2-4-15(23-16(12)11-14)5-6-17(24)13-7-9-22-10-8-13/h1-11H/b6-5+
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/pfk-158
Citation: https://aac.asm.org/content/early/2019/04/09/AAC.00271-19

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