Compound ID | 1318

Update compound information

DS86760016

Class: Aminoacyl-tRNA synthetase inhibitor (leucyl-tRNA synthetase [LeuRs] inhibitor)

Spectrum of activity: Gram-negative
Details of activity: DS86760016 showed potent activity against extended-spectrum multidrug-resistant Pseudomonas aeruginosa isolated from clinical samples and in vitro biofilms.
Institute where first reported: Department of Microbiology, Daiichi Sankyo India Pharma Pvt. Ltd., Gurugram, Haryana, India; Department of Pharmacokinetics and Metabolism, Daiichi Sankyo India Pharma Pvt. Ltd., Gurugram, Haryana, India; Department of Immunology, Inflammation and Metabolism, Division of Translational Medicine, SIDRA Medicine, Doha, Qatar; Amity Institute of Virology and Immunology, Amity University, Noida, India
Highest developmental phase: Preclinical
Development status: Active
Chemical structure(s):
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Molecular weight: 243.45
Iso. SMILES: B1(C2=C(C=CC3=C2OCO3)[C@H](O1)CN)O.Cl
InChI Key: FYHCZFHPLJMBAX-OGFXRTJISA-N
Can. SMILES: C1=C2[C@@H](CN)OB(C2=C3C(=C1)OCO3)O.Cl
InChI: InChI=1S/C9H10BNO4.ClH/c11-3-7-5-1-2-6-9(14-4-13-6)8(5)10(12)15-7;/h1-2,7,12H,3-4,11H2;1H/t7-;/m1./s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/140793266
Citation: https://aac.asm.org/content/63/4/e02122-18

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