Compound ID | 1319

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Indolmycin

Class: Aminoacyl-tRNA synthetase inhibitor (tryptophanyl-tRNA synthetase [TrpS] inhibitor)

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Antimycobacterial
Mechanism of action: Protein synthesis inhibitor. Aminoacyl-tRNA synthetase inhibitor (tryptophanyl-tRNA synthetase [TrpS] inhibitor)
Target Pathogen: Active against methicillin-susceptible and -resistant Staphylococcus aureus, vancomycin-intermediate Staphylococcus aureus, and strains resistant to mupirocin or fusidic acid
Institute where first reported: Chas. Pfizer & Co., Inc., Groton, Connecticut
Year first mentioned: 1980
Development status: Experimental
Chemical structure(s):
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Molecular weight: 257.29
Iso. SMILES: C[C@@H]([C@H]1C(=O)NC(=NC)O1)C2=CNC3=CC=CC=C32
InChI Key: GNTVWGDQPXCYBV-PELKAZGASA-N
Can. SMILES: C[C@H](C1=CNC2=C1C=CC=C2)[C@H]3C(=O)NC(=NC)O3
InChI: InChI=1S/C14H15N3O2/c1-8(12-13(18)17-14(15-2)19-12)10-7-16-11-6-4-3-5-9(10)11/h3-8,12,16H,1-2H3,(H,15,17,18)/t8-,12+/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/135417159
Guide to Pharmacology: indolmycin
Citations:
  • https://academic.oup.com/jac/article/54/2/549/767563
  • https://doi.org/10.1021/acschembio.1c00394
  • https://aac.asm.org/content/18/6/858.short

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