Compound ID | 1320

Update compound information

Lactivicin

Synonym(s): LTV

Class: Natural product antibiotic

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Cell wall synthesis inhibitor. PBP inhibitor
Target Pathogen: Moderately active against a wide range of Gram-negative bacteria and highly active against Gram-positive bacteria
Institute where first reported: Applied Microbiology Laboratories, Central Research Division, Takeda Chemical Industries, Ltd., Yodogawa-ku, Osaka 532, Japan
Year first mentioned: 1986
Development status: Experimental
Chemical structure(s):
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Molecular weight: 272.21
Iso. SMILES: CC(=O)NC1CON(C1=O)C2(CCC(=O)O2)C(=O)O
InChI Key: ZUEKKUYIXILDAF-UHFFFAOYSA-N
Can. SMILES: CC(=O)NC1CON(C1=O)C2(CCC(=O)O2)C(=O)O
InChI: InChI=1S/C10H12N2O7/c1-5(13)11-6-4-18-12(8(6)15)10(9(16)17)3-2-7(14)19-10/h6H,2-4H2,1H3,(H,11,13)(H,16,17)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/9881937
Guide to Pharmacology: lactivicin
Citations:
  • https://www.jstage.jst.go.jp/article/antibiotics1968/42/1/42_1_84/_article
  • https://doi.org/10.1038/nchembio.2007.21
  • https://www.sciencedirect.com/science/article/pii/S0040403900854398
    • Patents:
  • US11780832B2
  • WO2019034700 A1
  • WO2019034701 A1
  • WO2019034702 A1
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