Lactivicin

Class: Cell-wall synthesis inhibitor (non-beta-lactam antibiotic)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Moderately active against a wide range of Gram-negative bacteria and highly active against Gram-positive bacteria.
Institute where first reported:	Applied Microbiology Laboratories, Central Research Division, Takeda Chemical Industries, Ltd., Yodogawa-ku, Osaka 532, Japan
Year first mentioned:	1986
Highest developmental phase:	Preclinical
Development status:	Active

Chemical structure(s):
Canonical SMILES:	CC(=O)NC1CON(C1=O)C2(CCC(=O)O2)C(=O)O
Isomeric SMILES:	CC(=O)NC1CON(C1=O)C2(CCC(=O)O2)C(=O)O
InChI:	InChI=1S/C10H12N2O7/c1-5(13)11-6-4-18-12(8(6)15)10(9(16)17)3-2-7(14)19-10/h6H,2-4H2,1H3,(H,11,13)(H,16,17)
InChI Key:	ZUEKKUYIXILDAF-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/9881937

External links:
Guide to Pharmacology:	lactivicin
Main Source:	https://www.sciencedirect.com/science/article/pii/S0040403900854398
Citation:	https://www.jstage.jst.go.jp/article/antibiotics1968/42/1/42_1_84/_article
Patents:	US11780832B2 WO2019034700 A1 WO2019034701 A1 WO2019034702 A1