Compound ID | 1321

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BVL-GSK098

Synonym(s): Alpibectir

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting; Antibiotic adjuvant;
Spectrum of activity: Antimycobacterial
Mechanism of action: Overcomes resistance to ethionamide; Transcription factor inhibitor
Target Pathogen: Active against Mycobacterium tuberculosis
Combined with other compounds: yes
Institute where first reported: Bioversys AG
Year first mentioned: 2009
Highest development stage: Phase 2 (NCT05473195)
Development status: Active
Chemical structure(s):
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Molecular weight: 332.24
Iso. SMILES: C1CN(CCC12CC(=NO2)C(F)(F)F)C(=O)CCC(F)(F)F
InChI Key: ZEAVKHMQTZBUND-UHFFFAOYSA-N
Can. SMILES: C(CC(F)(F)F)C(=O)N1CCC2(CC1)CC(=NO2)C(F)(F)F
InChI: InChI=1S/C12H14F6N2O2/c13-11(14,15)2-1-9(21)20-5-3-10(4-6-20)7-8(19-22-10)12(16,17)18/h1-7H2
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/137500045
Guide to Pharmacology: alpibectir
Citations:
  • https://doi.org/10.1093/jac/dkae107
  • https://doi.org/10.1016/j.idnow.2023.104807
  • https://www.imi.europa.eu/projects-results/project-factsheets/tric-tb

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