Compound ID | 1323

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Niclosamide

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Membrane-active agent. Likely dissipation of proton motive force
Combined with other compounds: Yes
Institute where first reported: Department of Chemistry, University of Manitoba, Winnipeg, Manitoba, Canada
Year first mentioned: 2018
Development status: Experimental
Chemical structure(s):
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Molecular weight: 327.12
Iso. SMILES: C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O
InChI Key: RJMUSRYZPJIFPJ-UHFFFAOYSA-N
Can. SMILES: C1=C(C=C(C(=C1)O)C(=O)NC2=CC=C(C=C2Cl)[N+](=O)[O-])Cl
InChI: InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/4477
Guide to Pharmacology: niclosamide
Citations:
  • https://doi.org/10.1093/jac/dkac319
  • https://aac.asm.org/content/63/4/e02574-18

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