Compound ID | 1329

Update compound information

ZTI-01

Synonym(s): Fosfonomycin  |  Antibiotic 833A  |  IV Fosfomycin  |  Contepo

Class: Phosphonate

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Cell wall synthesis inhibitor
Target Pathogen: Active against pathogens causing uncomplicated urinary tract infections (acute cystitis) in women such as susceptible strains of Escherichia coli and Enterococcus faecalis
Description: Fosfomycin for Injection/intravenous
Institute where first reported: Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USADepartment of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin, USAWilliam S. Middleton Memorial VA Hospital, Madison, Wisconsin, USA
Highest development stage: Approved by FDA in 2025
Development status: Approved
Chemical structure(s):
Click here for structure editor
Molecular weight: 138.06
Iso. SMILES: C[C@H]1[C@H](O1)P(=O)(O)O
InChI Key: YMDXZJFXQJVXBF-STHAYSLISA-N
Can. SMILES: C[C@H]1[C@H](O1)P(=O)(O)O
InChI: InChI=1S/C3H7O4P/c1-2-3(7-2)8(4,5)6/h2-3H,1H3,(H2,4,5,6)/t2-,3+/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/446987
Guide to Pharmacology: fosfomycin
Citations:
  • https://www.ncbi.nlm.nih.gov/pubmed/24202878
  • https://doi.org/10.1093/cid/ciz181
  • https://aac.asm.org/content/61/6/e00476-17

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