ZTI-01 (Fosfomycin for Injection)

Synonym(s): Fosfomycin  |  Fosfonomycin  |  Antibiotic 833A

Class: Phosphonic acid antibacterial

Spectrum of activity:	Gram-negative
Details of activity:	For the treatment of uncomplicated urinary tract infections (acute cystitis) in women due to susceptible strains of Escherichia coli and Enterococcus faecalis; inhibits cell wall synthesis
Institute where first reported:	Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USADepartment of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin, USAWilliam S. Middleton Memorial VA Hospital, Madison, Wisconsin, USA
Highest developmental phase:	Phase 4
Development status:	Active

Chemical structure(s):
Canonical SMILES:	C[C@H]1[C@H](O1)P(=O)(O)O
Isomeric SMILES:	C[C@H]1[C@H](O1)P(=O)(O)O
InChI:	InChI=1S/C3H7O4P/c1-2-3(7-2)8(4,5)6/h2-3H,1H3,(H2,4,5,6)/t2-,3+/m0/s1
InChI Key:	YMDXZJFXQJVXBF-STHAYSLISA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/446987

External links:
Guide to Pharmacology:	fosfomycin
Main Source:	https://aac.asm.org/content/61/6/e00476-17
Citations:	https://pubchem.ncbi.nlm.nih.gov/compound/446987 https://www.ncbi.nlm.nih.gov/pubmed/24202878