Compound ID | 1331

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N2,N4-disubstituted Quinazoline-2,4-Diamines

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting; Antibiofilm;
Spectrum of activity: Gram-negative
Mechanism of action: Folate synthesis inhibitor. Dihydrofolate reductase inhibitor/ DHFR inhibitor
Target Pathogen: Active against Acinetobacter baumannii
Institute where first reported: Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, Florida, USA Center for Drug Discovery and Innovation, University of South Florida, Tampa, Florida, USA
Development status: Experimental
Chemical structure(s):
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Molecular weight: 298.77
Iso. SMILES: ClC1=CC=C2N=C(NCC3=CC=CC=C3)N=C(NC)C2=C1
InChI Key: WOHWNJFQZRICSK-UHFFFAOYSA-N
Can. SMILES: CNC1=NC(=NC2=CC=C(C=C21)Cl)NCC3=CC=CC=C3
InChI: InChI=1S/C16H15ClN4/c1-18-15-13-9-12(17)7-8-14(13)20-16(21-15)19-10-11-5-3-2-4-6-11/h2-9H,10H2,1H3,(H2,18,19,20,21)
External links:
Citation: https://aac.asm.org/content/61/6/e00059-17

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