Compound ID | 1359

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PQ401

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Membrane-active agent
Target Pathogen: Active against both multidrug-resistant and susceptible Staphylococcus aureus
Description: A diarylurea derivative
Institute where first reported: R&D Systems, MN
Year first mentioned: 2020
Highest development stage: Preclinical
Development status: Experimental
Chemical structure(s):
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Molecular weight: 341.79
Iso. SMILES: CC1=NC2=CC=CC=C2C(=C1)NC(=O)NC3=C(C=CC(=C3)Cl)OC
InChI Key: YBLWOZUPHDKFOT-UHFFFAOYSA-N
Can. SMILES: CC1=CC(=C2C=CC=CC2=N1)NC(=O)NC3=CC(=CC=C3OC)Cl
InChI: InChI=1S/C18H16ClN3O2/c1-11-9-15(13-5-3-4-6-14(13)20-11)21-18(23)22-16-10-12(19)7-8-17(16)24-2/h3-10H,1-2H3,(H2,20,21,22,23)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/9549305
Citation: https://mbio.asm.org/content/11/3/e01140-20

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