Compound ID | 136

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GP-2

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: DNA synthesis inhibitor. Bacterial topoisomerase inhibitor
Target Pathogen: Active against multidrug-resistant Pseudomonas aeruginosa
Propensity to select resistant mutants: Yes
Institute where first reported: Trius Therapeutics, USA
Year first mentioned: 2013
Development status: Experimental
Chemical structure(s):
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Molecular weight: 462.52
Iso. SMILES: CC=1N=CC(=CN1)OC2=NC=3NC4=C(C3C(N5C[C@@]6([C@H](N)C[C@]6(C)C5)C)=N2)C=C(C=C4NC)F
InChI Key: YWFYHCXQOBBCDF-UOKFIYJESA-N
Can. SMILES: CC1=NC=C(C=N1)OC2=NC(=C3C4=CC(=CC(=C4NC3=N2)NC)F)N5C[C@@]6(C)C[C@H]([C@@]6(C)C5)N
InChI: InChI=1S/C24H27FN8O/c1-12-28-8-14(9-29-12)34-22-31-20-18(15-5-13(25)6-16(27-4)19(15)30-20)21(32-22)33-10-23(2)7-17(26)24(23,3)11-33/h5-6,8-9,17,27H,7,10-11,26H2,1-4H3,(H,30,31,32)/t17-,23-,24-/m1/s1
External links:
Citations:
  • http://aac.asm.org/content/57/6/2887.full
  • https://journals.asm.org/doi/full/10.1128/aac.01740-12

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