Compound ID | 137

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GP-4

Agent Type: Synthetic; Small molecule; Direct acting;
Mechanism of action: DNA synthesis inhibitor. Bacterial topoisomerase inhibitor
Institute where first reported: Cubist Pharmaceuticals (Merck) USA
Year first mentioned: 2014
Development status: Experimental
Chemical structure(s):
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Molecular weight: 434.47
Iso. SMILES: CC1=NC=C(C=N1)OC2=NC3=C(C4=C(N3)C(=CC(=C4)F)NC)C(=N2)N5C[C@@H](C6(C5)CC6)N
InChI Key: VPJXVKBZNMZOOA-INIZCTEOSA-N
Can. SMILES: CC1=NC=C(C=N1)OC2=NC(=C3C4=CC(=CC(=C4NC3=N2)NC)F)N5C[C@@H](C6(CC6)C5)N
InChI: InChI=1S/C22H23FN8O/c1-11-26-7-13(8-27-11)32-21-29-19-17(14-5-12(23)6-15(25-2)18(14)28-19)20(30-21)31-9-16(24)22(10-31)3-4-22/h5-8,16,25H,3-4,9-10,24H2,1-2H3,(H,28,29,30)/t16-/m0/s1
External links:
Structure link: https://pubchem.ncbi.nlm.nih.gov/compound/66560933
Citations:
  • https://journals.asm.org/doi/full/10.1128/aac.01740-12
  • https://journals.asm.org/doi/full/10.1128/aac.01740-12

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