Compound ID | 1377

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Pyrrolomycin D

Class: Natural product antibiotic

Spectrum of activity: Gram-positive
Details of activity: Lower MICs than Ciprofloxacin against S. aureus and S.pneumoniae. Ineffective against Gram negative bacteria.
Description: Natural product from Actinosporangium
Institute where first reported: UNMC Center for Drug Discovery and Department of Pharmaceutical Sciences
Year first mentioned: 1983
Highest developmental phase: Preclinical
Chemical structure(s):
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Molecular weight: 359.42
Iso. SMILES: C1=C(C=C(C(=C1C(=O)C2=C(C(=C(N2)Cl)Cl)Cl)O)Cl)Cl
InChI Key: IJODRMYZNYTFTC-UHFFFAOYSA-N
Can. SMILES: C1=C(C(=C(C=C1Cl)Cl)O)C(=O)C2=C(C(=C(Cl)N2)Cl)Cl
InChI: InChI=1S/C11H4Cl5NO2/c12-3-1-4(9(18)5(13)2-3)10(19)8-6(14)7(15)11(16)17-8/h1-2,17-18H
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/133780
Citations:
  • https://aac.asm.org/content/63/10/e01450-19

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