Compound ID | 1383

Update compound information

Xeruborbactam

Synonym(s): QPX-7728  |  ORAvance  |  OMNIvance

Class: Beta-lactamase inhibitor

Spectrum of activity: Gram-negative
Details of activity: Active against Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii
Description: To be paired with beta-lactams for ORAvance and OMNIvance
Institute where first reported: Qpex Biopharma; Brii Biosciences
Year first mentioned: 2020
Highest development stage: Phase 1 (NCT04380207)
Development status: Active (as of 2024)
Chemical structure(s):
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Molecular weight: 221.98
Iso. SMILES: B1([C@@H]2C[C@@H]2C3=C(O1)C(=C(C=C3)F)C(=O)O)O
InChI Key: KOHUFVUIYUCFNG-PHDIDXHHSA-N
Can. SMILES: C1=C2[C@H]3C[C@H]3B(O)OC2=C(C(=C1)F)C(=O)O
InChI: InChI=1S/C10H8BFO4/c12-7-2-1-4-5-3-6(5)11(15)16-9(4)8(7)10(13)14/h1-2,5-6,15H,3H2,(H,13,14)/t5-,6-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/140830474
Guide to Pharmacology: xeruborbactam
Citations:
  • https://aac.asm.org/content/64/6/e00130-20
  • https://aac.asm.org/content/early/2020/05/27/AAC.00757-20/article-info?versioned=true
  • https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b01976
  • https://aac.asm.org/content/64/6/e00212-20

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