Thioridazine

Class: Phenothiazine

Spectrum of activity:	Gram-positive
Details of activity:	MRSA. Has also shown to make MRSA sensitive to Beta-lactam antibiotics
Institute where first reported:	Novartis, Switzerland
Highest developmental phase:	Approved by FDA in 1962
Development status:	Discontinued
Reason Dropped:	Caused severe cardiac arrhythmias

Chemical structure(s):
Canonical SMILES:	CN1CCCCC1CCN2C3=C(C=CC=C3)SC4=CC=C(C=C42)SC
Isomeric SMILES:	CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)SC
InChI:	InChI=1S/C21H26N2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
InChI Key:	KLBQZWRITKRQQV-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/5452

External links:
Guide to Pharmacology:	thioridazine
Main Source:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2203271/
Citation:	https://aac.asm.org/content/64/7/e00181-20