Compound ID | 1408

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Thioridazine

Class: Phenothiazine

Spectrum of activity: Gram-positive
Details of activity: MRSA. Has also shown to make MRSA sensitive to Beta-lactam antibiotics
Institute where first reported: Novartis, Switzerland
Highest developmental phase: Approved by FDA in 1962
Development status: Discontinued
Reason Dropped: Caused severe cardiac arrhythmias
Chemical structure(s):
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Molecular weight: 370.58
Iso. SMILES: CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)SC
InChI Key: KLBQZWRITKRQQV-UHFFFAOYSA-N
Can. SMILES: CN1CCCCC1CCN2C3=C(C=CC=C3)SC4=CC=C(C=C42)SC
InChI: InChI=1S/C21H26N2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5452
Guide to Pharmacology: thioridazine
Citations:
  • https://aac.asm.org/content/64/7/e00181-20
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2203271/

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