Clofazimine

Synonym(s): Lamprene

Class: Riminophenazine

Details of activity:	Antimycobacterial properties (used against Mycobacterium avium and Mycobacterium leprae)
Institute where first reported:	Novartis, Switzerland
Year first mentioned:	1986
Highest developmental phase:	Approved by FDA in 1986
Development status:	Approved
Reason Dropped:	Production discontinued by Novartis in US

Chemical structure(s):
Canonical SMILES:	CC(C)N=C1C=C2C(=NC3=C(C=CC=C3)N2C4=CC=C(C=C4)Cl)C=C1NC5=CC=C(C=C5)Cl
Isomeric SMILES:	CC(C)N=C1C=C2C(=NC3=CC=CC=C3N2C4=CC=C(C=C4)Cl)C=C1NC5=CC=C(C=C5)Cl
InChI:	InChI=1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3
InChI Key:	WDQPAMHFFCXSNU-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/2794

External links:
Guide to Pharmacology:	clofazimine
Main Source:	https://www.jaad.org/article/0190-9622(95)90134-5/pdf
Citation:	https://aac.asm.org/content/64/5/e02349-19