Compound ID | 1420

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Clofazimine

Synonym(s): Lamprene

Class: Riminophenazine

Details of activity: Antimycobacterial properties (used against Mycobacterium avium and Mycobacterium leprae)
Institute where first reported: Novartis, Switzerland
Year first mentioned: 1986
Highest developmental phase: Approved by FDA in 1986
Development status: Approved
Reason Dropped: Production discontinued by Novartis in US
Chemical structure(s):
Click here for structure editor
Molecular weight: 473.4
Iso. SMILES: CC(C)N=C1C=C2C(=NC3=CC=CC=C3N2C4=CC=C(C=C4)Cl)C=C1NC5=CC=C(C=C5)Cl
InChI Key: WDQPAMHFFCXSNU-UHFFFAOYSA-N
Can. SMILES: CC(C)N=C1C=C2C(=NC3=C(C=CC=C3)N2C4=CC=C(C=C4)Cl)C=C1NC5=CC=C(C=C5)Cl
InChI: InChI=1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/2794
Guide to Pharmacology: clofazimine
Citations:
  • https://aac.asm.org/content/64/5/e02349-19
  • https://www.jaad.org/article/0190-9622(95)90134-5/pdf

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