GSK3036656

Synonym(s): GSK656  |  Ganfeborole

Class: Aminoacyl-tRNA synthetase inhibitor (leucyl-tRNA synthetase [LeuRs] inhibitor)

Details of activity:	Active against Mycobacterium tuberculosis and M. abscessus
Institute where first reported:	GSK, USA
Year first mentioned:	2019
Highest developmental phase:	Phase 2

Chemical structure(s):
Canonical SMILES:	C1=C(C2=C(C(=C1)OCCO)B(O)O[C@@H]2CN)Cl
Isomeric SMILES:	B1(C2=C(C=CC(=C2[C@H](O1)CN)Cl)OCCO)O
InChI:	InChI=1S/C10H13BClNO4/c12-6-1-2-7(16-4-3-14)10-9(6)8(5-13)17-11(10)15/h1-2,8,14-15H,3-5,13H2/t8-/m1/s1
InChI Key:	DJUOWOXTPXUHDQ-MRVPVSSYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/133080621

External links:
Guide to Pharmacology:	ganfeborole
Main Source:	https://aac.asm.org/content/64/2/e01577-19