Compound ID | 1422

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GSK3036656

Synonym(s): GSK656  |  Ganfeborole

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Antimycobacterial
Mechanism of action: Protein synthesis inhibitor. Aminoacyl-tRNA synthetase inhibitor (leucyl-tRNA synthetase [LeuRs] inhibitor)
Target Pathogen: Active against Mycobacterium tuberculosis and Mycobacterium abscessus
Institute where first reported: GSK, USA
Year first mentioned: 2019
Highest development stage: Phase 2
Development status: Active
Chemical structure(s):
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Molecular weight: 257.48
Iso. SMILES: B1(C2=C(C=CC(=C2[C@H](O1)CN)Cl)OCCO)O
InChI Key: DJUOWOXTPXUHDQ-MRVPVSSYSA-N
Can. SMILES: C1=C(C2=C(C(=C1)OCCO)B(O)O[C@@H]2CN)Cl
InChI: InChI=1S/C10H13BClNO4/c12-6-1-2-7(16-4-3-14)10-9(6)8(5-13)17-11(10)15/h1-2,8,14-15H,3-5,13H2/t8-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/133080621
Guide to Pharmacology: ganfeborole
Citations:
  • https://doi.org/10.1038/s41591-024-02829-7
  • https://aac.asm.org/content/64/2/e01577-19

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