Compound ID | 1429

Update compound information

Verapamil

Class: Drug efflux pump inhibitor

Agent Type: Synthetic; Small molecule; Direct acting; Antibiotic adjuvant;
Spectrum of activity: Antimycobacterial
Mechanism of action: Efflux pump inhibitor. ABC family inhibitor
Target Pathogen: Active against Mycobacterium abscessus
Year first mentioned: 1981
Development status: Experimental
Chemical structure(s):
Click here for structure editor
Molecular weight: 454.6
Iso. SMILES: CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC
InChI Key: SGTNSNPWRIOYBX-UHFFFAOYSA-N
Can. SMILES: CC(C)C(CCCN(C)CCC1=CC=C(C(=C1)OC)OC)(C#N)C2=CC=C(C(=C2)OC)OC
InChI: InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/2520
Guide to Pharmacology: verapamil
Citations:
  • https://www.annualreviews.org/doi/10.1146/annurev.pa.36.040196.001113
  • https://aac.asm.org/content/63/9/e00705-19

    • AntibioticDB is supported by GARDP.

    If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

    The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.