ACHN-975

Class: Lipopolysaccharide synthesis inhibitor (LpxC inhibitor)

Spectrum of activity:	Gram-negative
Details of activity:	Gram negative effective
Institute where first reported:	Achaogen, USA
Year first mentioned:	2012
Highest developmental phase:	Phase 1
Development status:	Discontinued
Reason Dropped:	Toxicity

Chemical structure(s):
Canonical SMILES:	CC(C)([C@@H](C(=O)NO)NC(=O)C1=CC=C(C#CC#C[C@@H]2C[C@H]2CO)C=C1)N
Isomeric SMILES:	CC(C)([C@@H](C(=O)NO)NC(=O)C1=CC=C(C=C1)C#CC#C[C@@H]2C[C@H]2CO)N
InChI:	InChI=1S/C20H23N3O4/c1-20(2,21)17(19(26)23-27)22-18(25)14-9-7-13(8-10-14)5-3-4-6-15-11-16(15)12-24/h7-10,15-17,24,27H,11-12,21H2,1-2H3,(H,22,25)(H,23,26)/t15-,16+,17-/m1/s1
InChI Key:	GOCUUDXEOKIQRU-IXDOHACOSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/71466517

External links:
Guide to Pharmacology:	ACHN-975
Main Source:	https://www.pharmacodia.com/yaodu/html/v1/chemicals/6654ce00c34e725d8517c795abb11cdc.html
Citations:	https://clinicaltrials.gov/ct2/show/NCT01597947 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930914/pdf/cshperspectmed-ANR-a025304.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811409/