Compound ID | 1434

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EJMCh4

Synonym(s): 5-bromo-2-(2-cyclohexylethyl)-1H-benzo[d]imidazole

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Antimycobacterial
Mechanism of action: Mycolic acid synthesis inhibitor. MmpL3 (mycolate flippase) inhibitor
Target Pathogen: Active against Mycobacterium tuberculosis
Description: A 1H-benzo[d]imidazole derivative
Institute where first reported: Medical University of Gdańsk, Poland
Year first mentioned: 2015
Development status: Experimental
Chemical structure(s):
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Molecular weight: 307.23
Iso. SMILES: BrC1=CC=C2NC(CCC3CCCCC3)=NC2=C1
InChI Key: KOZCKNHBGNZSES-UHFFFAOYSA-N
Can. SMILES: C1CCC(CC1)CCC2=NC3=C(C=CC(=C3)Br)N2
InChI: InChI=1S/C15H19BrN2/c16-12-7-8-13-14(10-12)18-15(17-13)9-6-11-4-2-1-3-5-11/h7-8,10-11H,1-6,9H2,(H,17,18)
External links:
Citations:
  • https://www.sciencedirect.com/science/article/pii/S0223523414009581?via%3Dihub
  • https://doi.org/10.1128/aac.00441-19

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