Compound ID | 1438

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Walrycin B

Synonym(s): 1,6-dimethyl-3-[4-(trifluoromethyl)phenyl]pyrimido[5,4-e][1,2,4]triazine-5,7-dione

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting; Antivirulence;
Spectrum of activity: Gram-positive
Mechanism of action: Two-component signal transduction system inhibitor; WalR inhibitor
Institute where first reported: Department of Bioscience, Graduate School of Agriculture, Kinki University, Nara, Japan
Year first mentioned: 2010
Development status: Experimental
Chemical structure(s):
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Molecular weight: 337.26
Iso. SMILES: CN1C2=NC(=O)N(C(=O)C2=NC(=N1)C3=CC=C(C=C3)C(F)(F)F)C
InChI Key: XRVMPTWWKLKLPB-UHFFFAOYSA-N
Can. SMILES: CN1C(=O)C2=NC(=NN(C)C2=NC1=O)C3=CC=C(C=C3)C(F)(F)F
InChI: InChI=1S/C14H10F3N5O2/c1-21-12(23)9-11(19-13(21)24)22(2)20-10(18-9)7-3-5-8(6-4-7)14(15,16)17/h3-6H,1-2H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/3164070
Guide to Pharmacology: walrycin B
Citation: https://pubmed.ncbi.nlm.nih.gov/20111065/

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