Compound ID | 1439

Update compound information

AZD9742

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: DNA synthesis inhibitor. DNA gyrase and topoisomerase IV inhibitor
Target Pathogen: Active against Staphylococcus aureus and Streptococcus pneumoniae
Institute where first reported: AstraZeneca, UK
Year first mentioned: 2009
Highest development stage: Phase 1 (NCT01154621)
Development status: Active
Chemical structure(s):
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Molecular weight: 463.5
Iso. SMILES: C1CN(C[C@H]([C@H]1NCC2=CC3=C(C=N2)OCCO3)F)CCN4C(=O)C=CC5=C4C=C(C=C5)C#N
InChI Key: JYJKOWWSKTWAJA-RTWAWAEBSA-N
Can. SMILES: C1=CC2=C(C=C1C#N)N(CCN3CC[C@@H]([C@@H](C3)F)NCC4=NC=C5C(=C4)OCCO5)C(=O)C=C2
InChI: InChI=1S/C25H26FN5O3/c26-20-16-30(7-8-31-22-11-17(13-27)1-2-18(22)3-4-25(31)32)6-5-21(20)29-14-19-12-23-24(15-28-19)34-10-9-33-23/h1-4,11-12,15,20-21,29H,5-10,14,16H2/t20-,21+/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/25008769
Citations:
  • https://doi.org/10.1021/jm300690s
  • https://www.sciencedirect.com/science/article/pii/S1471489214001064

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