Compound ID | 1442

Update compound information

Posizolid

Synonym(s): AZD 2563  |  AZD-5847  |  AZD-2563  |  AZD2563  |  AZD 5847  |  AZD5847

Class: Oxazolidinone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Active against Staphylococcus aureus, coagulase-negative staphylococci, Enterococcus spp., Streptococcus pneumoniae, other Streptococcus spp. and Corynebacterium;
Institute where first reported: AstraZeneca, UK
Year first mentioned: 2004
Highest development stage: Phase 2 (NCT01516203)
Development status: Inactive
Chemical structure(s):
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Molecular weight: 465.4
Iso. SMILES: C1CN(CC=C1C2=C(C=C(C=C2F)N3C[C@@H](OC3=O)COC4=NOC=C4)F)C(=O)[C@H](CO)O
InChI Key: HBUJYEUPIIJJOS-PBHICJAKSA-N
Can. SMILES: C1=C(CCN(C1)C(=O)[C@H](CO)O)C2=C(C=C(C=C2F)N3C[C@H](COC4=NOC=C4)OC3=O)F
InChI: InChI=1S/C21H21F2N3O7/c22-15-7-13(26-9-14(33-21(26)30)11-31-18-3-6-32-24-18)8-16(23)19(15)12-1-4-25(5-2-12)20(29)17(28)10-27/h1,3,6-8,14,17,27-28H,2,4-5,9-11H2/t14-,17+/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/213049
Guide to Pharmacology: posizolid
Citations:
  • https://pubmed.ncbi.nlm.nih.gov/15008947/
  • https://doi.org/10.1111/j.1198-743x.2004.00770.x

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