Posizolid

Synonym(s): AZD 2563  |  AZD-5847

Class: Oxazolidinone

Spectrum of activity:	Gram-positive
Details of activity:	Active against S. aureus, coagulase-negative staphylococci, Enterococcus spp., Streptococcus pneumoniae, other Streptococcus spp. and Corynebacterium; at 2mg/L, inhibits 98% of all Gram-positive bacteria in vitro
Institute where first reported:	AstraZeneca, UK
Year first mentioned:	2004
Highest developmental phase:	Preclinical

Chemical structure(s):
Canonical SMILES:	C1=C(CCN(C1)C(=O)[C@H](CO)O)C2=C(C=C(C=C2F)N3C[C@H](COC4=NOC=C4)OC3=O)F
Isomeric SMILES:	C1CN(CC=C1C2=C(C=C(C=C2F)N3C[C@@H](OC3=O)COC4=NOC=C4)F)C(=O)[C@H](CO)O
InChI:	InChI=1S/C21H21F2N3O7/c22-15-7-13(26-9-14(33-21(26)30)11-31-18-3-6-32-24-18)8-16(23)19(15)12-1-4-25(5-2-12)20(29)17(28)10-27/h1,3,6-8,14,17,27-28H,2,4-5,9-11H2/t14-,17+/m1/s1
InChI Key:	HBUJYEUPIIJJOS-PBHICJAKSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/213049

External links:
Guide to Pharmacology:	posizolid
Main Source:	https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(14)63107-4/fulltext
Citations:	https://pubchem.ncbi.nlm.nih.gov/compound/Posizolid https://pubmed.ncbi.nlm.nih.gov/15008947/