Ceftaroline

Synonym(s): Ceftaroline fosamil

Class: Beta-lactam (cephalosporin)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Anti-MRSA and Enterobacteriaceae; indicated for acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia
Institute where first reported:	Forest Laboratories, USA/ AbbVie/ Allergan/ Cerexa Inc.
Year first mentioned:	2008
Highest developmental phase:	Approved by FDA in 2010; Approved for pediatric use in 2016

Chemical structure(s):
Canonical SMILES:	CCO/N=C(/C1=NSC(=N1)NP(=O)(O)O)\C(=O)N[C@@H]2C(=O)N3C(=C(CS[C@H]23)SC4=NC(=CS4)C5=CC=[N+](C)C=C5)C(=O)[O-]
Isomeric SMILES:	CCO/N=C(/C1=NSC(=N1)NP(=O)(O)O)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)SC4=NC(=CS4)C5=CC=[N+](C=C5)C)C(=O)[O-]
InChI:	InChI=1S/C22H21N8O8PS4/c1-3-38-26-13(16-25-21(43-28-16)27-39(35,36)37)17(31)24-14-18(32)30-15(20(33)34)12(9-40-19(14)30)42-22-23-11(8-41-22)10-4-6-29(2)7-5-10/h4-8,14,19H,3,9H2,1-2H3,(H4-,24,25,27,28,31,33,34,35,36,37)/b26-13-/t14-,19-/m1/s1
InChI Key:	ZCCUWMICIWSJIX-NQJJCJBVSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/9852981
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/9938701

External links:
Guide to Pharmacology:	ceftaroline fosamil
Main Source:	https://aac.asm.org/content/53/6/2360
Citations:	https://academic.oup.com/jac/article/74/2/425/5150590?searchresult=1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140339/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157143/