Compound ID | 1449

Update compound information

Nitazoxanide

Synonym(s): Alinia

Class: Small molecule antibacterial agent

Agent Type: Small molecule;
Spectrum of activity: Gram-positive & Antimycobacterial
Mechanism of action: Unknown
Target Pathogen: Active against Mycobacterium tuberculosis and Clostridioides difficile
Description: A thiazolide
Institute where first reported: Romark Laboratories, USA
Year first mentioned: 1980
Highest development stage: Approved by FDA in 2005 as antiprotozoal drug
Development status: Approved
Reason dropped: Other formulations were discontinued
Chemical structure(s):
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Molecular weight: 307.28
Iso. SMILES: CC(=O)OC1=CC=CC=C1C(=O)NC2=NC=C(S2)[N+](=O)[O-]
InChI Key: YQNQNVDNTFHQSW-UHFFFAOYSA-N
Can. SMILES: CC(=O)OC1=C(C=CC=C1)C(=O)NC2=NC=C([N+](=O)[O-])S2
InChI: InChI=1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/41684
Citations:
  • https://www.nature.com/articles/s41429-020-0288-3
  • https://aac.asm.org/content/64/5/e01956-19

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