Compound ID | 1451

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Linezolid

Synonym(s): Zyvox

Class: Oxazolidinone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Protein synthesis inhibitor
Target Pathogen: Active against methicillin-resistant Staphylococcus aureus and Streptococcus sp.
Institute where first reported: Pfizer, USA
Year first mentioned: 1990
Highest development stage: Approved by FDA in 2000
Development status: Approved
Chemical structure(s):
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Molecular weight: 337.35
Iso. SMILES: CC(=O)NC[C@H]1CN(C(=O)O1)C2=CC(=C(C=C2)N3CCOCC3)F
InChI Key: TYZROVQLWOKYKF-ZDUSSCGKSA-N
Can. SMILES: CC(=O)NC[C@H]1CN(C2=CC=C(C(=C2)F)N3CCOCC3)C(=O)O1
InChI: InChI=1S/C16H20FN3O4/c1-11(21)18-9-13-10-20(16(22)24-13)12-2-3-15(14(17)8-12)19-4-6-23-7-5-19/h2-3,8,13H,4-7,9-10H2,1H3,(H,18,21)/t13-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/441401
Guide to Pharmacology: linezolid
Citation: https://link.springer.com/article/10.1007%2Fs40262-017-0601-x

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