Compound ID | 1454

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Redx04739

Class: Bacterial topoisomerase inhibitor

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Antimycobacterial activity. Also active against S. aureus, E.coli,and M.smegmatis
Institute where first reported: Norwich Research Park, Uk
Year first mentioned: 2020
Highest developmental phase: Preclinical
Chemical structure(s):
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Molecular weight: 424.43
Iso. SMILES: CNC1=C2C(C=3C(N4CCC(N)C4)=NC(CNC(C5=CN=CO5)=O)=NC3N2)=CC(F)=C1
InChI Key: BANJIAOWENUTAO-UHFFFAOYSA-N
Can. SMILES: CNC1=C2C(=CC(=C1)F)C3=C(N=C(CNC(=O)C4=CN=CO4)N=C3N2)N5CCC(C5)N
InChI: InChI=1S/C20H21FN8O2/c1-23-13-5-10(21)4-12-16-18(28-17(12)13)26-15(7-25-20(30)14-6-24-9-31-14)27-19(16)29-3-2-11(22)8-29/h4-6,9,11,23H,2-3,7-8,22H2,1H3,(H,25,30)(H,26,27,28)
External links:
Citation: https://academic.oup.com/jac/article-abstract/75/10/2835/5878045?redirectedFrom=fulltext

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