Solithromycin

Class: Macrolide (16-membered macrolide, fluoroketolide)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Community-acquired bacterial pneumonia, uncomplicated urogenital gonorrhoea, urethritis
Institute where first reported:	Toyama Chemical Co. Ltd./Melinta Therapeutics Inc.
Year first mentioned:	2008
Highest developmental phase:	Phase 3
Development status:	Active

Chemical structure(s):
Canonical SMILES:	CC[C@@H]1[C@]2(C)[C@@H]([C@@H](C)C(=O)[C@H](C)C[C@](C)([C@@H]([C@@H](C)C(=O)[C@@](C)(C(=O)O1)F)O[C@H]3[C@@H]([C@H](C[C@@H](C)O3)N(C)C)O)OC)N(CCCCN4C=C(C5=CC(=CC=C5)N)N=N4)C(=O)O2
Isomeric SMILES:	CC[C@@H]1[C@@]2([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H](C(=O)[C@](C(=O)O1)(C)F)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)N(C(=O)O2)CCCCN4C=C(N=N4)C5=CC(=CC=C5)N)C
InChI:	InChI=1S/C43H65FN6O10/c1-12-32-43(8)35(50(40(55)60-43)19-14-13-18-49-23-30(46-47-49)28-16-15-17-29(45)21-28)26(4)33(51)24(2)22-41(6,56-11)37(27(5)36(53)42(7,44)39(54)58-32)59-38-34(52)31(48(9)10)20-25(3)57-38/h15-17,21,23-27,31-32,34-35,37-38,52H,12-14,18-20,22,45H2,1-11H3/t24-,25-,26+,27+,31+,32-,34-,35-,37-,38+,41-,42+,43-/m1/s1
InChI Key:	IXXFZUPTQVDPPK-ZAWHAJPISA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/25242512

External links:
Guide to Pharmacology:	solithromycin
Main Source:	http://ir.melinta.com/news-releases/news-release-details/cempras-solithromycin-cem-101-receives-qualified-infectious
Citations:	http://aac.asm.org/content/57/9/4322.full http://aac.asm.org/content/58/1/447.full