Compound ID | 1467

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Macfarlandin H

Class: Natural product antibiotic

Details of activity: Antimycobacterial activity against Mycobacterium tuberculosis
Description: Natural product from Samoan marine sponge Chelonaplysilla sp.
Institute where first reported: University of British Columbia, CA
Year first mentioned: 2020
Highest developmental phase: Preclinical
Chemical structure(s):
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Molecular weight: 376.49
Iso. SMILES: O=C1C[C@@H](COC(C)=O)[C@](CO1)([H])[C@]2([C@H](C)C=3[C@](CC2)([H])C(C)(C)CC(C3)=O)C
InChI Key: IJQNURYWVMNEIT-BPEFAXCUSA-N
Can. SMILES: C[C@@H]1C2=CC(=O)CC(C)(C)[C@]2([H])CC[C@@]1(C)[C@]3([H])COC(=O)C[C@H]3COC(=O)C
InChI: InChI=1S/C22H32O5/c1-13-17-9-16(24)10-21(3,4)18(17)6-7-22(13,5)19-12-27-20(25)8-15(19)11-26-14(2)23/h9,13,15,18-19H,6-8,10-12H2,1-5H3/t13-,15+,18-,19-,22-/m1/s1
External links:
Citation: https://www.nature.com/articles/s41429-020-0315-4

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