CRS3123

Synonym(s): REP3123

Class: Aminoacyl-tRNA synthetase inhibitor (methionyl tRNA synthetase [MetRS] inhibitor)

Spectrum of activity:	Gram-positive
Details of activity:	Clostridium difficile infection
Institute where first reported:	Crestone, USA
Year first mentioned:	2007
Highest developmental phase:	Phase 2 (NCT04781387)
Development status:	Active (as of 2025)

Chemical structure(s):
Canonical SMILES:	C(CN[C@@H]1CCOC2=C(C=C(C=C12)Br)Br)CNC3=CC(=O)C4=C(C=CS4)N3
Isomeric SMILES:	C1COC2=C([C@@H]1NCCCNC3=CC(=O)C4=C(N3)C=CS4)C=C(C=C2Br)Br
InChI:	InChI=1S/C19H19Br2N3O2S/c20-11-8-12-14(2-6-26-18(12)13(21)9-11)22-4-1-5-23-17-10-16(25)19-15(24-17)3-7-27-19/h3,7-10,14,22H,1-2,4-6H2,(H2,23,24,25)/t14-/m1/s1
InChI Key:	NNTYBKTXMKBRFA-CQSZACIVSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/16744283

External links:
Guide to Pharmacology:	CRS3123
Main Source:	https://www.crestonepharma.com/index.php/cdi
Citations:	http://jac.oxfordjournals.org/content/63/5/954.long https://www.ncbi.nlm.nih.gov/pubmed/28134686 https://www.ncbi.nlm.nih.gov/pubmed/28584140