Compound ID | 149

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CRS3123

Synonym(s): REP3123  |  REP 3123  |  REP-3123  |  CRS 3123  |  CRS-3123

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Protein synthesis inhibitor. Aminoacyl-tRNA synthetase inhibitor (methionyl tRNA synthetase [MetRS] inhibitor)
Target Pathogen: Active against Clostridium difficile
Description: Synthetic compound
Institute where first reported: Crestone, USA
Year first mentioned: 2007
Highest developmental phase: Phase 2 (NCT04781387)
Development status: Active (as of 2025)
Chemical structure(s):
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Molecular weight: 513.25
Iso. SMILES: C1COC2=C([C@@H]1NCCCNC3=CC(=O)C4=C(N3)C=CS4)C=C(C=C2Br)Br
InChI Key: NNTYBKTXMKBRFA-CQSZACIVSA-N
Can. SMILES: C(CN[C@@H]1CCOC2=C(C=C(C=C12)Br)Br)CNC3=CC(=O)C4=C(C=CS4)N3
InChI: InChI=1S/C19H19Br2N3O2S/c20-11-8-12-14(2-6-26-18(12)13(21)9-11)22-4-1-5-23-17-10-16(25)19-15(24-17)3-7-27-19/h3,7-10,14,22H,1-2,4-6H2,(H2,23,24,25)/t14-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/16744283
Guide to Pharmacology: CRS3123
Citations:
  • http://jac.oxfordjournals.org/content/63/5/954.long
  • https://www.ncbi.nlm.nih.gov/pubmed/28134686
  • https://www.ncbi.nlm.nih.gov/pubmed/28584140
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC7187627/

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