Compound ID | 150

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Aztreonam + Avibactam

Class: Beta-lactam (monobactam) + beta-lactamase inhibitor (non-beta-lactam beta-lactamase inhibitor, diazabicyclooctane [DBO])

Spectrum of activity: Gram-negative
Details of activity: Metallo-β-lactamase-producing gram-negative organisms such as Enterobacteriaceae and Pseudomonas aeruginosa
Combined with other compounds: Yes
Institute where first reported: Pfizer Inc./Allergan PLC (formerly Actavis)
Year first mentioned: 2012
Highest developmental phase: Phase 3 (NCT03329092)
Development status: Active (as of 2024)
External links:
Guide to Pharmacology: aztreonam
Citations:
  • http://aac.asm.org/content/57/7/3299.full
  • https://aac.asm.org/content/61/9/e00472-17

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