Compound ID | 1534

Update compound information

Muraminomicin G

Class: MraY inhibitor (nucleoside antibiotic)

Spectrum of activity: Gram-positive
Details of activity: Interferes with cell-wall synthesis by inhibiting transfer of the peptidoglycan precursor moiety (MurNAc-pentapeptide) to the membrane lipid carrier, undecaprenyl phosphate. Active against Staphylococcus
Description: Muraminomicin derivative
Institute where first reported: Medicinal Chemistry Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan
Year first mentioned: 2019
Highest developmental phase: Preclinical
Chemical structure(s):
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Molecular weight: 898.01
Iso. SMILES: CCCCCCCCCCCC(CC(=O)OC1CN(C(C(=O)N(C1C(=O)O)C)C([C@@H]2[C@H](C[C@@H](O2)N3C=CC(=O)NC3=O)O)O[C@H]4C[C@@H]([C@H](O4)CN)O)C)OC(=O)CC(C)CC(=O)O
InChI Key: FCSOGCDVKHVDDF-DHTOFOGASA-N
Can. SMILES: CCCCCCCCCCCC(CC(=O)OC1CN(C)C(C([C@@H]2[C@H](C[C@H](N3C=CC(=O)NC3=O)O2)O)O[C@H]4C[C@@H]([C@@H](CN)O4)O)C(=O)N(C)C1C(=O)O)OC(=O)CC(C)CC(=O)O
InChI: InChI=1S/C42H67N5O16/c1-5-6-7-8-9-10-11-12-13-14-25(59-33(53)18-24(2)17-32(51)52)19-34(54)60-29-23-45(3)37(40(55)46(4)36(29)41(56)57)39(63-35-21-26(48)28(22-43)61-35)38-27(49)20-31(62-38)47-16-15-30(50)44-42(47)58/h15-16,24-29,31,35-39,48-49H,5-14,17-23,43H2,1-4H3,(H,51,52)(H,56,57)(H,44,50,58)/t24?,25?,26-,27-,28+,29?,31+,35-,36?,37?,38-,39?/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/145720732
Citation: https://www.nature.com/articles/s41429-019-0235-3

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