Compound ID | 1537

Update compound information

Muraminomicin Z2

Class: MraY inhibitor (nucleoside antibiotic)

Spectrum of activity: Gram-positive
Details of activity: Interferes with cell-wall synthesis by inhibiting transfer of the peptidoglycan precursor moiety (MurNAc-pentapeptide) to the membrane lipid carrier, undecaprenyl phosphate. Active against Staphylococcus
Description: Muraminomicin derivative
Institute where first reported: Medicinal Chemistry Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan
Year first mentioned: 2019
Highest developmental phase: Preclinical
Chemical structure(s):
Click here for structure editor
Molecular weight: 525.51
Iso. SMILES: CN1CC=C(N(C(=O)C1C([C@@H]2[C@H](C[C@@H](O2)N3C=CC(=O)NC3=O)O)O[C@H]4C[C@@H]([C@H](O4)CN)O)C)C(=O)O
InChI Key: KHAQYZWENFAJLP-MKZGKKIISA-N
Can. SMILES: CN1CC=C(C(=O)O)N(C)C(=O)C1C([C@@H]2[C@H](C[C@H](N3C=CC(=O)NC3=O)O2)O)O[C@H]4C[C@@H]([C@@H](CN)O4)O
InChI: InChI=1S/C22H31N5O10/c1-25-5-3-10(21(32)33)26(2)20(31)17(25)19(37-16-8-11(28)13(9-23)35-16)18-12(29)7-15(36-18)27-6-4-14(30)24-22(27)34/h3-4,6,11-13,15-19,28-29H,5,7-9,23H2,1-2H3,(H,32,33)(H,24,30,34)/t11-,12-,13+,15+,16-,17?,18-,19?/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/145720724
Citation: https://www.nature.com/articles/s41429-019-0235-3

AntibioticDB is supported by GARDP.

If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.