Compound ID | 1547

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2-(pyrazol-1-yl)- thiazole Compound 2

Class: Protein synthesis inhibitor

Spectrum of activity: Gram-negative
Details of activity: Antimicrobial activity against E.coli
Institute where first reported: Institute of Biochemistry and Genetics Russian Academy of Science, Russia
Year first mentioned: 2019
Highest developmental phase: Preclinical
Chemical structure(s):
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Molecular weight: 374.43
Iso. SMILES: FC1=CC=C(NC(CCC2=C(O)N(C3=NC(C)=C(C)S3)N=C2C)=O)C=C1
InChI Key: XKFWUXGILBOLGA-UHFFFAOYSA-N
Can. SMILES: CC1=C(C)SC(=N1)N2C(=C(CCC(=O)NC3=CC=C(C=C3)F)C(=N2)C)O
InChI: InChI=1S/C18H19FN4O2S/c1-10-12(3)26-18(20-10)23-17(25)15(11(2)22-23)8-9-16(24)21-14-6-4-13(19)5-7-14/h4-7,25H,8-9H2,1-3H3,(H,21,24)
External links:
Citation: https://www.nature.com/articles/s41429-019-0211-y

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