Compound ID | 1548

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2-(pyrazol-1-yl)- thiazole Compound 3

Class: Protein synthesis inhibitor

Spectrum of activity: Gram-negative
Details of activity: Antimicrobial activity against E.coli
Institute where first reported: Institute of Biochemistry and Genetics Russian Academy of Science, Russia
Year first mentioned: 2019
Highest developmental phase: Preclinical
Chemical structure(s):
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Molecular weight: 360.41
Iso. SMILES: O=C(CC1=C(O)N(C2=NC(C)=C(C)S2)N=C1C)NC3=CC=CC=C3F
InChI Key: VJDPOIFAJSKATR-UHFFFAOYSA-N
Can. SMILES: CC1=C(C)SC(=N1)N2C(=C(CC(=O)NC3=C(C=CC=C3)F)C(=N2)C)O
InChI: InChI=1S/C17H17FN4O2S/c1-9-11(3)25-17(19-9)22-16(24)12(10(2)21-22)8-15(23)20-14-7-5-4-6-13(14)18/h4-7,24H,8H2,1-3H3,(H,20,23)
External links:
Citation: https://www.nature.com/articles/s41429-019-0211-y

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