Compound ID | 1552

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2-(pyrazol-1-yl)- thiazole Compound 7

Class: Protein synthesis inhibitor

Spectrum of activity: Gram-negative
Details of activity: Antimicrobial activity against E.coli
Institute where first reported: Institute of Biochemistry and Genetics Russian Academy of Science, Russia
Year first mentioned: 2019
Highest developmental phase: Preclinical
Chemical structure(s):
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Molecular weight: 410.42
Iso. SMILES: OC1=C(CC(NC2=CC(C(F)(F)F)=CC=C2)=O)C(C)=NN1C3=NC(C)=C(C)S3
InChI Key: IOAWAAHDAMJLLK-UHFFFAOYSA-N
Can. SMILES: CC1=C(C)SC(=N1)N2C(=C(CC(=O)NC3=CC(=CC=C3)C(F)(F)F)C(=N2)C)O
InChI: InChI=1S/C18H17F3N4O2S/c1-9-11(3)28-17(22-9)25-16(27)14(10(2)24-25)8-15(26)23-13-6-4-5-12(7-13)18(19,20)21/h4-7,27H,8H2,1-3H3,(H,23,26)
External links:
Citation: https://www.nature.com/articles/s41429-019-0211-y

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