Compound ID | 1553

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2-(pyrazol-1-yl)- thiazole Compound 8

Class: Protein synthesis inhibitor

Spectrum of activity: Gram-negative
Details of activity: Antimicrobial activity against E.coli
Institute where first reported: Institute of Biochemistry and Genetics Russian Academy of Science, Russia
Year first mentioned: 2019
Highest developmental phase: Preclinical
Chemical structure(s):
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Molecular weight: 384.45
Iso. SMILES: O=C(CC1=C(O)N(C2=NC(C)=C(C)S2)N=C1C)NC3=CC=C(C(C)=O)C=C3
InChI Key: UNWVWCHMSSWNDH-UHFFFAOYSA-N
Can. SMILES: CC1=C(C)SC(=N1)N2C(=C(CC(=O)NC3=CC=C(C=C3)C(=O)C)C(=N2)C)O
InChI: InChI=1S/C19H20N4O3S/c1-10-13(4)27-19(20-10)23-18(26)16(11(2)22-23)9-17(25)21-15-7-5-14(6-8-15)12(3)24/h5-8,26H,9H2,1-4H3,(H,21,25)
External links:
Citation: https://www.nature.com/articles/s41429-019-0211-y

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