Compound ID | 156

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Glyceryl Trinitrate + Citrate + Ethanol

Synonym(s): Glyceryl Trinitrate  |  GTN-CAP  |  GTN

Class: Antibiofilm agent

Agent Type: Synthetic; Small molecule; Direct acting; Antibiofilm;
Spectrum of activity: Gram-positive
Mechanism of action: Anaerobe pyruvate:ferredoxin oxidoreductase inhibitor (PFOR inhibitor)
Target Pathogen: Active against biofilms of methicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa
Combined with other compounds: Yes
Description: Combined with citrate and ethanol; also shows anti-Candida biofilm activity
Institute where first reported: Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA
Year first mentioned: 2013
Development status: Experimental
Chemical structure(s):
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Molecular weight: 227.09
Iso. SMILES: C(C(CO[N+](=O)[O-])O[N+](=O)[O-])O[N+](=O)[O-]
InChI Key: SNIOPGDIGTZGOP-UHFFFAOYSA-N
Can. SMILES: C(C(CO[N+](=O)[O-])O[N+](=O)[O-])O[N+](=O)[O-]
InChI: InChI=1S/C3H5N3O9/c7-4(8)13-1-3(15-6(11)12)2-14-5(9)10/h3H,1-2H2
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/4510
Citation: http://aac.asm.org/content/57/8/3555.full
Patent: US9913820B2

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