Compound ID | 1570

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NPS-2143 derivative 19

Class: CaSR antagonist

Spectrum of activity: Gram-positive
Details of activity: Antimicrobial activity against Staphylococcus aureus and MRSA
Institute where first reported: Department of Medicinal Chemistry, Chengdu, China
Year first mentioned: 2019
Highest developmental phase: Preclinical
Chemical structure(s):
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Molecular weight: 412.45
Iso. SMILES: O[C@H](CNC(C)(C)CC1=CC=C2C=CC=CC2=C1)COC3=CC=C([N+]([O-])=O)C=C3F
InChI Key: FSAOMKQPVYTGPS-HXUWFJFHSA-N
Can. SMILES: CC(C)(CC1=CC2=C(C=CC=C2)C=C1)NC[C@H](COC3=CC=C(C=C3F)[N+](=O)[O-])O
InChI: InChI=1S/C23H25FN2O4/c1-23(2,13-16-7-8-17-5-3-4-6-18(17)11-16)25-14-20(27)15-30-22-10-9-19(26(28)29)12-21(22)24/h3-12,20,25,27H,13-15H2,1-2H3/t20-/m1/s1
External links:
Citation: https://www.nature.com/articles/s41429-019-0177-9

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