Compound ID | 1573

Update compound information

NPS-2143 derivative 22

Class: CaSR antagonist

Spectrum of activity: Gram-positive
Details of activity: Antimicrobial activity against Staphylococcus aureus and MRSA
Institute where first reported: Department of Medicinal Chemistry, Chengdu, China
Year first mentioned: 2019
Highest developmental phase: Preclinical
Chemical structure(s):
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Molecular weight: 393.48
Iso. SMILES: O[C@H](CNC(C)(C)CC1=CC=C2C=CC=CC2=C1)COC3=CC=4OCOC4C=C3
InChI Key: YYSYQUFXUJXTGU-HXUWFJFHSA-N
Can. SMILES: CC(C)(CC1=CC2=C(C=CC=C2)C=C1)NC[C@H](COC3=CC=C4C(=C3)OCO4)O
InChI: InChI=1S/C24H27NO4/c1-24(2,13-17-7-8-18-5-3-4-6-19(18)11-17)25-14-20(26)15-27-21-9-10-22-23(12-21)29-16-28-22/h3-12,20,25-26H,13-16H2,1-2H3/t20-/m1/s1
External links:
Citation: https://www.nature.com/articles/s41429-019-0177-9

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