Compound ID | 1574

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NPS-2143 derivative 23

Class: CaSR antagonist

Spectrum of activity: Gram-positive
Details of activity: Antimicrobial activity against Staphylococcus aureus and MRSA
Institute where first reported: Department of Medicinal Chemistry, Chengdu, China
Year first mentioned: 2019
Highest developmental phase: Preclinical
Chemical structure(s):
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Molecular weight: 394.46
Iso. SMILES: O[C@H](CNC(C)(C)CC1=CC=C2C=CC=CC2=C1)COC3=CC([N+]([O-])=O)=CC=C3
InChI Key: LVRJNRLXBFBNHX-OAQYLSRUSA-N
Can. SMILES: CC(C)(CC1=CC2=C(C=CC=C2)C=C1)NC[C@H](COC3=CC(=CC=C3)[N+](=O)[O-])O
InChI: InChI=1S/C23H26N2O4/c1-23(2,14-17-10-11-18-6-3-4-7-19(18)12-17)24-15-21(26)16-29-22-9-5-8-20(13-22)25(27)28/h3-13,21,24,26H,14-16H2,1-2H3/t21-/m1/s1
External links:
Citation: https://www.nature.com/articles/s41429-019-0177-9

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