Compound ID | 1575

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NPS-2143 derivative 24

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Indirect acting;
Spectrum of activity: Gram-positive
Mechanism of action: CaSR antagonist; regulates host immune response
Target Pathogen: Active against methicillin-resistant and -susceptible Staphylococcus aureus
Institute where first reported: Department of Medicinal Chemistry, Chengdu, China
Year first mentioned: 2019
Development status: Experimental
Chemical structure(s):
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Molecular weight: 419.56
Iso. SMILES: O[C@H](CNC(C)(C)CC1=CC=C2C=CC=CC2=C1)COC3=CC=C(C(CCC)=O)C=C3
InChI Key: DQUHVJIYQCHKAS-XMMPIXPASA-N
Can. SMILES: CCCC(=O)C1=CC=C(C=C1)OC[C@@H](CNC(C)(C)CC2=CC3=C(C=CC=C3)C=C2)O
InChI: InChI=1S/C27H33NO3/c1-4-7-26(30)22-12-14-25(15-13-22)31-19-24(29)18-28-27(2,3)17-20-10-11-21-8-5-6-9-23(21)16-20/h5-6,8-16,24,28-29H,4,7,17-19H2,1-3H3/t24-/m1/s1
External links:
Citation: https://www.nature.com/articles/s41429-019-0177-9

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