Compound ID | 1576

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NPS-2143 derivative 25

Class: CaSR antagonist

Spectrum of activity: Gram-positive
Details of activity: Antimicrobial activity against Staphylococcus aureus and MRSA
Institute where first reported: Department of Medicinal Chemistry, Chengdu, China
Year first mentioned: 2019
Highest developmental phase: Preclinical
Chemical structure(s):
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Molecular weight: 458.39
Iso. SMILES: O[C@H](CNC(C)(C)CC1=CC=C2C=CC=CC2=C1)COC3=CC(Br)=CC=C3OC
InChI Key: QDXTWESCCVIVOV-OAQYLSRUSA-N
Can. SMILES: CC(C)(CC1=CC2=C(C=CC=C2)C=C1)NC[C@H](COC3=CC(=CC=C3OC)Br)O
InChI: InChI=1S/C24H28BrNO3/c1-24(2,14-17-8-9-18-6-4-5-7-19(18)12-17)26-15-21(27)16-29-23-13-20(25)10-11-22(23)28-3/h4-13,21,26-27H,14-16H2,1-3H3/t21-/m1/s1
External links:
Citation: https://www.nature.com/articles/s41429-019-0177-9

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