Compound ID | 1577

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NPS-2143 derivative 26

Class: CaSR antagonist

Spectrum of activity: Gram-positive
Details of activity: Antimicrobial activity against Staphylococcus aureus and MRSA
Institute where first reported: Department of Medicinal Chemistry, Chengdu, China
Year first mentioned: 2019
Highest developmental phase: Preclinical
Chemical structure(s):
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Molecular weight: 374.48
Iso. SMILES: O[C@H](CNC(C)(C)CC1=CC=C2C=CC=CC2=C1)COC3=CC(C#N)=CC=C3
InChI Key: BVKQUIFWZUSNGY-JOCHJYFZSA-N
Can. SMILES: CC(C)(CC1=CC2=C(C=CC=C2)C=C1)NC[C@H](COC3=CC(=CC=C3)C#N)O
InChI: InChI=1S/C24H26N2O2/c1-24(2,14-18-10-11-20-7-3-4-8-21(20)12-18)26-16-22(27)17-28-23-9-5-6-19(13-23)15-25/h3-13,22,26-27H,14,16-17H2,1-2H3/t22-/m1/s1
External links:
Citation: https://www.nature.com/articles/s41429-019-0177-9

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