Compound ID | 1579

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NPS-2143 derivative 28

Class: CaSR antagonist

Spectrum of activity: Gram-positive
Details of activity: Antimicrobial activity against Staphylococcus aureus and MRSA
Institute where first reported: Department of Medicinal Chemistry, Chengdu, China
Year first mentioned: 2019
Highest developmental phase: Preclinical
Chemical structure(s):
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Molecular weight: 379.49
Iso. SMILES: O[C@H](CNC(C)(C)CC1=CC=C2C=CC=CC2=C1)COC3=CC(OC)=CC=C3
InChI Key: RNEHDMXYTCDKMA-OAQYLSRUSA-N
Can. SMILES: CC(C)(CC1=CC2=C(C=CC=C2)C=C1)NC[C@H](COC3=CC(=CC=C3)OC)O
InChI: InChI=1S/C24H29NO3/c1-24(2,15-18-11-12-19-7-4-5-8-20(19)13-18)25-16-21(26)17-28-23-10-6-9-22(14-23)27-3/h4-14,21,25-26H,15-17H2,1-3H3/t21-/m1/s1
External links:
Citation: https://www.nature.com/articles/s41429-019-0177-9

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